Faculty Profile

Prof. Surajit Ganguly

Email : surajit.ganguly@jamiahamdard.ac.in


Research Area :

Neurosciences, Neuro-immune Interaction, Impact of peripheral infection in the CNS. The central thrust of my laboratory at JH-IMM is to understand how pathogens via neuro-immune interactions modulate neuronal functions in brain, particularly in the hippocampus. Masters or PhD students interested to work in my lab should directly contact me at surajit.ganguly@jamiahamdard.ac.in


Name : Prof. Surajit Ganguly

Gender : Male

Birth Date : -

Designation : Team Lead Scientist

Department : Molecular Medicine

URL :

Date of Joining : 07/06/2019

UG Courses :

PG Courses : MSc and BSc (FYUP) in Biomedical Sciences, MPharm in Pharmacy

Address :

City : -

State : -

Country : -

Email Address : surajit.ganguly@jamiahamdard.ac.in

Phone [Residence] : -

Phone [Mobile] : -

No. Degree/Diploma Institute/ Organization Year Branch/Specialization
1 Ph. D.  (Philosophy of Doctorate ) 1998 CSIR/Indian Institute of Chemical Biology
No. Publication Journal Month Year
1 Abdullah A, Kumar A, Beg AZ, Chawla A, Kar S, Ganguly S*, Khan AU*. Peripherally-restricted recurrent infection by engineered E. coli strain modulates hippocampal proteome promoting memory impairments in a rat model. Gene. 2025 Jan 15;933:148969. doi: 10.1016 *Corresponding authors. 2025
2 Kriti Jain, Anika Goel, Deepa Mehra, Deepak Kumar Rathore, Akshay Binayke, Shyam Aggarwal, Surajit Ganguly, Amit Awasthi, Evanka Madan and Nirmal Kumar Ganguly. Cytokine profiling identifies circulating IL-2, IL23 and sPD-L1 as prognostic biomarkers for treatment outcomes in non-small cell Lung Cancer patients undergoing anti-PD1 therapy. Journal: Frontiers in Oncology 10.3389/fonc.2025.1628379 2025
3 Gaur V, Tyagi W, Das S, Ganguly S, Bhattacharyya J. CD40 agonist engineered immunosomes modulated tumor microenvironment and showed pro-immunogenic response, reduced toxicity, and tumor free survival in mice bearing glioblastoma. Biomaterials. 2024 Dec;311:122688. doi: 10.1016/j.biomaterials.2024.122688. Epub 2024 Jun 25. PMID: 38943821. 2024
4 Sarkar S, Ganguly S, Ganguly NK, Sarkar DP, Sharma NR. Chandipura Virus Forms Cytoplasmic Inclusion Bodies through Phase Separation and Proviral Association of Cellular Protein Kinase R and Stress Granule Protein TIA-1. Viruses. 2024 Jun 26;16(7):1027. doi: 10.3390/v16071027. PMID: 39066190; PMCID: PMC11281494. 2024
5 Kumar J, Dhyani S, Kumar P, Sharma NR, Ganguly S. (2023) SARS-CoV-2-encoded ORF8 protein possesses complement inhibitory properties. J Biol Chem. 299(3):102930. doi: 10.1016/j.jbc.2023.102930. Epub ahead of print. PMID: 36682494; PMCID: PMC9851726. 2023
6 Anjali Barnwal, Surajit Ganguly, and Jayanta Bhattacharyya (2023) Multifaceted Nano-DEV-IL for Sustained Release of IL-12 to Avert the Immunosuppressive Tumor Microenvironment and IL-12-Associated Toxicities. ACS Applied Materials & Interfaces Article ASAP DOI: 10.1021/acsami.3c02934 2023
7 Jain, Kriti; Rathore, Deepak K.; Ganguly, Surajit; et al.. Case report: Correlation of immune profiling and exceptional response to immune checkpoint inhibitor in a patient with head and neck cancer. Journal of Cancer Research and Therapeutics ():, May 25, 2023. | DOI: 10.4103/jcrt.jcrt_2339_22. 2023
8 Kriti Jain, Shyam Aggarwal, Surajit Ganguly, Nirmal Kumar Ganguly, Amit Awasthi, Deepa Mehra (2022) Biomarkers to predict response to immune checkpoint inhibitor therapy in Cancer. IJIRT 9 (5): 205-221 2022
9 Arnab Choudhury, Bhawna Solanki, Seema Singh, Upasana Sahu, Suhel Parvez, Sudeshna Kar and Surajit Ganguly (2019) Persistent peripheral presence of Staphylococcus aureus promotes histone H3 hypoacetylation and decreases tyrosine hydroxylase protein level in rat brain tissues. NeuroReport Sept 9, 2019. doi: 10.1097/WNR.0000000000001322. 2019
10 Ganguly S, Seth S. A translational perspective on histone acetylation modulators in psychiatric disorders. Psychopharmacology (Berl). Psychopharmacology (Berl). 2018 Jul;235(7):1867-1873. 2018
11 Choudhury A, Singh S, Palit G, Shukla S, Ganguly S (2016) Administration of N-acetylserotonin and melatonin alleviate chronic ketamine-induced behavioural phenotype accompanying BDNF-independent and dependent converging cytoprotective mechanisms in the hippocampus. Behav Brain Res. 297:204-212. 2016
12 Singh S, Choudhury A, Gusain P, Parvez S, Palit G, Shukla S, Ganguly S (2016) Oral acetate supplementation attenuates N-methyl D-aspartate receptor hypofunction-induced behavioral phenotypes accompanied by restoration of acetyl-histone homeostasis. Psychopharmacology (Berl). 233(7):1257-68. 2016
13 Bose S, Ganguly S, Kumar S, Boockfor FR. (2016) A Pit-1 Binding Site Adjacent to E-box133 in the Rat PRL Promoter is Necessary for Pulsatile Gene Expression Activity. Neurochem Res. 41(6):1390-400. 2016
14 Chatterjee M, Verma R, Ganguly S,* and Palit G *(2012) Neurochemical and molecular characterization of ketamine induced experimental psychosis model in mice. Neuropharmacology. 63 (6):1161-1171;*Corresponding authors 2012
15 Chatterjee M, Ganguly S, Srivastava M, Palit G. (2011) Effect of 'chronic' versus 'acute' ketamine administration and its 'withdrawal' effect on behavioural alterations in mice: implications for experimental psychosis. Behav Brain Res. 216(1):247-54. 2011
16 Klein DC, Bailey MJ, Carter DA, Kim JS, Shi Q, Ho AK, Chik CL, Gaildrat P, Morin F, Ganguly S, Rath MF, Møller M, Sugden D, Rangel ZG, Munson PJ, Weller JL, Coon SL. (2010) Pineal function:impact of microarray analysis. Mol Cell Endocrinol. 314(2):170-83. 2010
17 Bailey MJ, Coon SL, Carter DA, Humphries A, Kim JS, Shi Q, Gaildrat P, Morin F, Ganguly S, Hogenesch JB, Weller JL, Rath MF, Møller M, Baler R, Sugden D, Rangel ZG, Munson PJ, Klein DC. (2009) Night/day changes in pineal expression of >600 genes: Central role of adrenergic/cAMP signaling. J Biol Chem. 284(12):7606-22. 2009
18 Pavlicek J, Coon SL, Ganguly S, Weller JL, Hassan SA, Sackett DL, Klein DC.(2008) Evidence that proline focuses movement of the floppy loop of arylalkylamine N-acetyltransferase (ec 2.3.1.87). J Biol Chem.;283(21):14552-8. 2008
19 Ganguly S, Grodzki C, Sugden D, et al (2007) Neural Adrenergic/Cyclic AMP Regulation of the Immunoglobulin E Receptor {alpha}-Subunit Expression in the Mammalian Pinealocyte: A Neuroendocrine/Immune Response Link? J Biol Chem. 282(45):32758-64. 2007
20 Szewczuk LM, Saldanha SA, Ganguly S, Bowers EM, Javoroncov M, Karanam B, Culhane JC, Holbert MA, Klein DC, Abagyan R, Cole PA. (2007) De novo discovery of serotonin N-acetyltransferase inhibitors. J Med Chem. 50(22):5330-8. 2007
21 Rath MF, Munoz E, Ganguly S, Morin F, Shi Q, Klein DC, Moller M. (2006) Expression of the Otx2 homeobox gene in the developing mammalian brain: embryonic and adult expression in the pineal gland. J Neurochem. 97(2):556-66. 2006
22 Ganguly S, Weller JL , Ho A , Chemineau P, Malpaux B, Klein DC (2005) Melatonin synthesis: 14-3-3-dependent activation and inhibition of arylalkylamine N-acetyltransferase mediated by phosphoserine-205. Proc Natl Acad Sci U S A. 2005 Jan 25;102(4):1222-7. 2005
23 Klein, D.C., Ganguly, S., Coon, S.L., Weller, J.L., Shi, Q., Gaildrat, P., Morin, F., Weller, J. L.Obsil, T., Hickman, A. and Dyda, F. (2003) 14-3-3 Proteins in pineal photoneuroendocrine transduction: How many roles? Journal of Neuroendocrinology 85: 851-60. 2003
24 Zheng W, Zhang Z, Ganguly S, Weller JL, Klein DC, Cole PA. (2003) Cellular stabilization of the melatonin rhythm enzyme induced by nonhydrolyzable phosphonate incorporation. Nature Struct and Mol. Biol. 10(12):1054-7. 2003
25 Ganguly S, Coon SL, Klein DC. (2002) Control of melatonin synthesis in the mammalian pineal gland: the critical role of serotonin acetylation. Cell Tissue Res. 2002 Jul;309(1):127-37. 2002
26 Obsil T, Ghirlando R, Klein DC, Ganguly S, Dyda F. (2001) Crystal structure of the 14-3- 3zeta:serotonin N-acetyltransferase complex. a role for scaffolding in enzyme regulation. Cell 105(2):257-267. 2001
27 Ganguly S, Gastel JA, Weller JL, Schwartz C, Jaffe H, Namboodiri MA, Coon SL, Hickman AB, Rollag M, Obsil T, Beauverger P, Ferry G, Boutin JA, Klein DC. (2001) Role of a pineal cAMPoperated arylalkylamine N-acetyltransferase/14-3-3-binding switch in melatonin synthesis. Proc Natl Acad Sci U S A 98(14):8083-8088. 2001
28 Ganguly S, Mummaneni P, Steinbach PJ, Klein DC, Coon SL. (2001) Characterization of the Saccharomyces cerevisiae Homolog of the Melatonin Rhythm Enzyme Arylalkylamine NAcetyltransferase EC 2.3.1.87). J Biol Chem 276(50):47239-47247 2001
29 Chakrabarti SR, Sood R, Ganguly S, Bohlander S, Shen Z, Nucifora G. (1999) Modulation of TEL transcription activity by interaction with the ubiquitin-conjugating enzyme UBC9. Proc Natl Acad Sci U S A 96 (13):7467-7472. 1999
No. Book Published Year
1 S Ganguly#, DC Klein (2017) The Timezyme and Melatonin: Essential Elements of Vertebrate Timekeeping In Biological Timekeeping: Clocks, Rhythms and Behaviour (Springer India; Vinod Kumar ed), pp 503-520 (Chapter) 2017
No. Patent Description Year
1 DRUG COMBINATION WITH CELLULAR ANTI-PROLIFERATIVE AND SELF-RENEWAL INHIBITING PROPERTIES. Application No.: 202311079808 dated November 27, 2023 2023
2 A CHIP AND A METHOD FOR HEAD & NECK CANCER PROGNOSIS - Application number: PCT/IN2019/050386 2019
No. Achievement Description Year
1 Prof. B Uvnas Prize (Gold Medal) from the Indian Pharmacological Society 2014
2 Award of Merit - National Institutes of Health, Maryland USA for discovering the regulation of night-time melatonin synthesis in higher vertebrates 2002